Therapeutic options targeting angiogenesis in nonsmall cell lung cancer
نویسندگان
چکیده
منابع مشابه
Therapeutic options targeting angiogenesis in nonsmall cell lung cancer.
There is a major unmet medical need for effective and well-tolerated treatment options for patients with advanced nonsmall cell lung cancer (NSCLC), in both first-line and relapsed/refractory settings. Experimental evidence has validated signalling pathways that regulate tumour angiogenesis, including the vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and fibro...
متن کاملTherapeutic management of ALK+ nonsmall cell lung cancer patients.
With therapeutic approaches based on oncogene addiction offering significant anticancer benefit, the identification of anaplastic lymphoma kinase (ALK) rearrangements is a key aspect of the management of lung cancers. The EML4-ALK gene fusion is detected in 4-8% of all lung cancers, predominantly in light smokers or nonsmokers. Crizotinib, the first agent to be approved in this indication, is a...
متن کاملTargeting Angiogenesis in Non-Small Cell Lung Cancer (NSCLC)
The management of NSCLC has undergone a paradigm shift in the last 5 years with the survival advantage demonstrated by the addition of bevacizumab to standard frontline platinum-based doublet specifically, paclitaxel and carboplatin. The increased toxicity observed in patients with squamous histology and in elderly patients treated with angiogenesis-targeting agents has led to even greater scru...
متن کاملStrategies targeting angiogenesis in advanced non-small cell lung cancer
Tumor angiogenesis is a frequent event in the development and progression of non-small cell lung cancer (NSCLC) and has been identified as a promising therapeutic target. The vascular endothelial growth factor (VEGF) family and other angiogenic factors, including fibroblast growth factor and platelet-derived growth factor, promote the growth of newly formed vessels from preexisting vessels and ...
متن کاملSurgery for nonsmall cell lung cancer.
Surgery remains the best curative option in patients with early stage lung cancer (stage I and II). Developments in minimally invasive techniques now allow surgeons to perform lung resections on elderly patients, patients with poor pulmonary function or significant cardiopulmonary comorbidities. New techniques, such as stereotactic radiotherapy and ablative procedures, are being evaluated in ea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Respiratory Review
سال: 2014
ISSN: 0905-9180,1600-0617
DOI: 10.1183/09059180.00008913